IMS Affiliated Faculty

Donald R Smith
  • Title
    • Professor
  • Division Physical & Biological Sciences Division
  • Department
    • Microbiology & Environmental Toxicology Department
    • Institute of Marine Sciences
    • Chemistry & Biochemistry Department
  • Phone
  • Email
  • Website
  • Office Location
    • Physical Sciences Building, 442
    • Physical Sciences Building 442
  • Mail Stop METX
  • Faculty Areas of Expertise Biomedical Sciences, Neuroscience

Summary of Expertise

Molecular, cellular, and organismal responses to metals. Neurotoxicology and therapeutic treatment of metal poisoning

Selected Publications

Finkelstein ME, Brandt, J, Sandhaus, E, Grantham, J, Mee, A, Schuppert PJ, Smith DR. Lead exposure risk from trash ingestion by the endangered California Condor (Gymnogyps californianus). Journal of Wildlife Diseases 2015,  51(4) (in press).

Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernández-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B. Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort. Environ Int. 2015 Jul 22;84:39-54. doi: 10.1016/j.envint.2015.07.009. [Epub ahead of print] PubMed PMID: 26209874.

Ferri R, Hashim D, Smith DR, Guazzetti S, Donna F, Ferretti E, Curatolo M, Moneta C, Beone GM, Lucchini RG. Metal contamination of home garden soils and cultivated vegetables in the province of Brescia, Italy: Implications for human exposure. Sci Total Environ. 2015 Jun 15;518-519:507-17. doi: 10.1016/j.scitotenv.2015.02.072. Epub 2015 Mar 13. PubMed PMID: 25777956; PubMed Central PMCID: PMC4388796.

Beaudin SA, Strupp BJ, Lasley SM, Fornal CA, Mandal S, Smith DR. Oral methylphenidate alleviates the fine motor dysfunction caused by chronic postnatal manganese exposure in adult rats. Toxicol Sci. 2015 Apr;144(2):318-27. doi: 10.1093/toxsci/kfv007. Epub 2015 Jan 19. PubMed PMID: 25601986; PubMed Central PMCID: PMC4372668.

Lucas EL, Bertrand P, Guazzetti S, Donna F, Peli M, Jursa TP, Lucchini R, Smith DR. Impact of ferromanganese alloy plants on household dust manganese levels: Implications for childhood exposure. Environ Res. 2015 Apr;138:279-90. doi: 10.1016/j.envres.2015.01.019. Epub 2015 Mar 4. PubMed PMID: 25747819; PubMed Central PMCID: PMC4385503.

Finkelstein ME, Kuspa ZE, Welch A, Eng C, Clark M, Burnett J, Smith DR. Linking cases of illegal shootings of the endangered California condor using stable lead isotope analysis. Environ Res. 2014 Oct;134:270-9. doi: 10.1016/j.envres.2014.07.022. Epub 2014 Aug 29. PubMed PMID: 25173094.

Mora AM, van Wendel de Joode B, Mergler D, Córdoba L, Cano C, Quesada R, Smith DR, Menezes-Filho JA, Eskenazi B.Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica.Environ Res. 2015 Jan;136:47-56. doi: 10.1016/j.envres.2014.10.011. Epub 2014 Nov 20. PubMed PMID: 25460620; PubMed Central PMCID: PMC4262687.

Gunier RB, Mora AM, Smith D, Arora M, Austin C, Eskenazi B, Bradman A. Biomarkers of manganese exposure in pregnant women and children living in an agricultural community in California. Environ Sci Technol. 2014 Dec 16;48(24):14695-702. doi: 10.1021/es503866a. Epub 2014 Nov 21. PubMed PMID: 25390650; PubMed Central PMCID: PMC4270392.

Lucchini RG, Guazzetti S, Zoni S, Benedetti C, Fedrighi C, Peli M, Donna F, Bontempi E, Borgese L, Micheletti S, Ferri R, Marchetti S, Smith DR. Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese.Neurotoxicology. 2014 Dec;45:309-17. doi: 10.1016/j.neuro.2014.05.006. Epub 2014 May 29. PubMed PMID: 24881811; PubMed Central PMCID: PMC4247810.

Gunier RB, Jerrett M, Smith DR, Jursa T, Yousefi P, Camacho J, Hubbard A, Eskenazi B, Bradman A. Determinants of manganese levels in house dust samples from the CHAMACOS cohort. Sci Total Environ. 2014 Nov 1;497-498:360-8. doi: 10.1016/j.scitotenv.2014.08.005. Epub 2014 Aug 19. PubMed PMID: 25146905; PubMed Central PMCID: PMC4177311.

Pavilonis BT, Lioy PJ, Guazzetti S, Bostick BC, Donna F, Peli M, Zimmerman NJ, Bertrand P, Lucas E, Smith DR, Georgopoulos PG, Mi Z, Royce SG, Lucchini RG. Manganese concentrations in soil and settled dust in an area with historic ferroalloy production. J Expo Sci Environ Epidemiol. 2014 Oct 22. doi: 10.1038/jes.2014.70. [Epub ahead of print] PubMed PMID: 25335867; PubMed Central PMCID: PMC4406789.

Hiolski EM, Kendrick PS, Frame ER, Myers MS, Bammler TK, Beyer RP, Farin FM, Wilkerson HW, Smith DR, Marcinek DJ, Lefebvre KA. Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquat Toxicol. 2014 Oct;155:151-9. doi: 10.1016/j.aquatox.2014.06.006. Epub 2014 Jun 20. PubMed PMID: 25033243; PubMed Central PMCID: PMC4139102.

Mora AM, van Wendel de Joode B, Mergler D, Córdoba L, Cano C, Quesada R, Smith DR, Menezes-Filho JA, Lundh T, Lindh CH, Bradman A, Eskenazi B. Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Rica. Environ Sci Technol. 2014 Mar 18;48(6):3467-76. doi: 10.1021/es404279r. Epub 2014 Mar 6. PubMed PMID: 24601641; PubMed Central PMCID: PMC3983325.

Ettinger AS, Roy A, Amarasiriwardena CJ, Smith D, Lupoli N, Mercado-García A, Lamadrid-Figueroa H, Tellez-Rojo MM, Hu H, Hernández-Avila M. Maternal blood, plasma, and breast milk lead: lactational transfer and contribution to infant exposure.Environ Health Perspect. 2014 Jan;122(1):87-92. doi: 10.1289/ehp.1307187. Epub 2013 Nov 1. PubMed PMID: 24184948; PubMed Central PMCID: PMC3888576.

Gunier RB, Bradman A, Jerrett M, Smith DR, Harley KG, Austin C, Vedar M, Arora M, Eskenazi B. Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community. Environ Sci Technol. 2013 Oct 1;47(19):11249-57. doi: 10.1021/es4018688. Epub 2013 Sep 23. PubMed PMID: 24053404; PubMed Central PMCID: PMC4167759.

Beaudin SA, Nisam S, Smith DR. Early life versus lifelong oral manganese exposure differently impairs skilled forelimb performance in adult rats. Neurotoxicol Teratol. 2013 Jul-Aug;38:36-45. doi: 10.1016/ Epub 2013 Apr 24. PubMed PMID: 23623961; PubMed Central PMCID: PMC3713098.

Bellinger DC, Burger J, Cade TJ, Cory-Slechta DA, Finkelstein M, Hu H, Kosnett M, Landrigan PJ, Lanphear B, Pokras MA, Redig PT, Rideout BA, Silbergeld E, Wright R, Smith DR. Health risks from lead-based ammunition in the environment.Environ Health Perspect. 2013 Jun;121(6):A178-9. doi: 10.1289/ehp.1306945. PubMed PMID: 23732085; PubMed Central PMCID: PMC3672933.

Smith, DR and Finkelstein, M., et al. 2013. Health risks from lead-based ammunition in the Environment: A consensus statement of scientists. eScholarship Open Source ( 

Borgese L, Federici S, Zacco A, Gianoncelli A, Rizzo L, Smith DR, Donna F, Lucchini R, Depero LE, Bontempi E. Metal fractionation in soils and assessment of environmental contamination in Vallecamonica, Italy. Environ Sci Pollut Res Int. 2013 Jul;20(7):5067-75. doi: 10.1007/s11356-013-1473-8. Epub 2013 Jan 22. PubMed PMID: 23338992; PubMed Central PMCID: PMC3688652.

Eastman RR, Jursa TP, Benedetti C, Lucchini RG, Smith DR. Hair as a biomarker of environmental manganese exposure.Environ Sci Technol. 2013 Feb 5;47(3):1629-37. doi: 10.1021/es3035297. Epub 2013 Jan 17. PubMed PMID: 23259818; PubMed Central PMCID: PMC3583582.

Masuda M, Braun-Sommargren M, Crooks D, Smith DR. Golgi phosphoprotein 4 (GPP130) is a sensitive and selective cellular target of manganese exposure. Synapse. 2013 May;67(5):205-15. doi: 10.1002/syn.21632. Epub 2013 Feb 8. PubMed PMID: 23280773; PubMed Central PMCID: PMC3987769.

Smith D, Strupp BJ. The scientific basis for chelation: animal studies and lead chelation. J Med Toxicol. 2013 Dec;9(4):326-38. doi: 10.1007/s13181-013-0339-2. Review. PubMed PMID: 24113857; PubMed Central PMCID: PMC3846979.

Kurle C, Finkelstein ME, Smith KR, George D, Ciani D, et al. Stable nitrogen and carbon isotope discrimination factors for blood and feathers from California condor (Gymnogyps californianus) chicks and juveniles. The Condor. 2013; (115):492-500.

Braun JM, Lucchini R, Bellinger DC, Hoffman E, Nazzaro M, Smith DR, Wright RO. Predictors of virtual radial arm maze performance in adolescent Italian children. Neurotoxicology. 2012 Oct;33(5):1203-11. doi: 10.1016/j.neuro.2012.06.012. Epub 2012 Jul 6. PubMed PMID: 22771383; PubMed Central PMCID: PMC3470779.

Finkelstein ME, Doak DF, George D, Burnett J, Brandt J, Church M, Grantham J, Smith DR. Lead poisoning and the deceptive recovery of the critically endangered California condor. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11449-54. doi: 10.1073/pnas.1203141109. Epub 2012 Jun 25. PubMed PMID: 22733770; PubMed Central PMCID: PMC3396531.

Lucchini RG, Guazzetti S, Zoni S, Donna F, Peter S, Zacco A, Salmistraro M, Bontempi E, Zimmerman NJ, Smith DR. Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission. Neurotoxicology. 2012 Aug;33(4):687-96. doi: 10.1016/j.neuro.2012.01.005. Epub 2012 Jan 31. PubMed PMID: 22322213; PubMed Central PMCID: PMC3360122.

Lucchini RG, Zoni S, Guazzetti S, Bontempi E, Micheletti S, Broberg K, Parrinello G, Smith DR. Inverse association of intellectual function with very low blood lead but not with manganese exposure in Italian adolescents. Environ Res. 2012 Oct;118:65-71. doi: 10.1016/j.envres.2012.08.003. Epub 2012 Aug 24. PubMed PMID: 22925625; PubMed Central PMCID: PMC3477579.

Ferri R, Donna F, Smith DR, Guazzetti S, Zacco A, et al. Heavy metals in soil and salad in the proximity of historical ferroalloy emission. J. Environ. Protec.. 2012; 3(5):374-385

Lefebvre KA, Frame ER, Gulland F, Hansen JD, Kendrick PS, Beyer RP, Bammler TK, Farin FM, Hiolski EM, Smith DR, Marcinek DJ. A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity.PLoS One. 2012;7(5):e36213. doi: 10.1371/journal.pone.0036213. Epub 2012 May 2. PubMed PMID: 22567140; PubMed Central PMCID: PMC3342169.

Arora M, Bradman A, Austin C, Vedar M, Holland N, Eskenazi B, Smith DR. Determining fetal manganese exposure from mantle dentine of deciduous teeth. Environ Sci Technol. 2012 May 1;46(9):5118-25. doi: 10.1021/es203569f. Epub 2012 Apr 11. PubMed PMID: 22455722; PubMed Central PMCID: PMC3341525.

Rideout BA, Stalis I, Papendick R, Pessier A, Puschner B, Finkelstein ME, Smith DR, Johnson M, Mace M, Stroud R, Brandt J, Burnett J, Parish C, Petterson J, Witte C, Stringfield C, Orr K, Zuba J, Wallace M, Grantham J. Patterns of mortality in free-ranging California Condors (Gymnogyps californianus). J Wildl Dis. 2012 Jan;48(1):95-112. PubMed PMID: 22247378.

Kern CH, Smith DR. Preweaning Mn exposure leads to prolonged astrocyte activation and lasting effects on the dopaminergic system in adult male rats. Synapse. 2011 Jun;65(6):532-44. doi: 10.1002/syn.20873. Epub 2010 Dec 3. PubMed PMID: 20963817; PubMed Central PMCID: PMC3070959.

Whittaker MH, Wang G, Chen XQ, Lipsky M, Smith D, Gwiazda R, Fowler BA. Exposure to Pb, Cd, and As mixtures potentiates the production of oxidative stress precursors: 30-day, 90-day, and 180-day drinking water studies in rats. Toxicol Appl Pharmacol. 2011 Jul 15;254(2):154-66. doi: 10.1016/j.taap.2010.10.025. Epub 2010 Oct 27. PubMed PMID: 21034764.

Arora M, Hare D, Austin C, Smith DR, Doble P. Spatial distribution of manganese in enamel and coronal dentine of human primary teeth. Sci Total Environ. 2011 Mar 1;409(7):1315-9. doi: 10.1016/j.scitotenv.2010.12.018. Epub 2011 Jan 5. PubMed PMID: 21211818.

Mukhopadhyay S, Bachert C, Smith DR, Linstedt AD. Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130. Mol Biol Cell. 2010 Apr 1;21(7):1282-92. doi: 10.1091/mbc.E09-11-0985. Epub 2010 Feb 3. PubMed PMID: 20130081; PubMed Central PMCID: PMC2847531.

Cantonwine D, Hu H, Sánchez BN, Lamadrid-Figueroa H, Smith D, Ettinger AS, Mercado-García A, Hernández-Avila M, Wright RO, Téllez-Rojo MM. Critical windows of fetal lead exposure: adverse impacts on length of gestation and risk of premature delivery. J Occup Environ Med. 2010 Nov;52(11):1106-11. doi: 10.1097/JOM.0b013e3181f86fee. PubMed PMID: 21063188; PubMed Central PMCID: PMC3003442.

Finkelstein ME, George D, Scherbinski S, Gwiazda R, Johnson M, Burnett J, Brandt J, Lawrey S, Pessier AP, Clark M, Wynne J, Grantham J, Smith DR. Feather lead concentrations and (207)Pb/(206)Pb ratios reveal lead exposure history of California Condors (Gymnogyps californianus). Environ Sci Technol. 2010 Apr 1;44(7):2639-47. doi: 10.1021/es903176w. PubMed PMID: 20199067.

Kern CH, Stanwood GD, Smith DR. Preweaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficits associated with altered dopamine receptor and transporter levels. Synapse. 2010 May;64(5):363-78. doi: 10.1002/syn.20736. PubMed PMID: 20029834; PubMed Central PMCID: PMC2840192.