IMS Affiliated Faculty

Victoria Auerbuch Stone
  • Title
    • Associate Professor
  • Division Physical & Biological Sciences Division
  • Department
    • Microbiology & Environmental Toxicology Department
  • Phone
  • Email
  • Fax
  • Website
  • Office Location
    • Biomedical Research Building 244
  • Mail Stop METX
  • Mailing Address
    • Mailstop: METX
  • Courses METX 119: Microbiology, METX 206A: Advanced Microbiology

Summary of Expertise

Bacterial pathogenesis.

Research Interests

Recognition of bacterial pathogens by the innate immune system is of utmost importance to human health. However, successful bacterial pathogens have evolved mechanisms to manipulate innate immune defenses. We use the human gut pathogen and model organism Yersinia pseudotuberculosis to probe how the mammalian innate immune system specifically recognizes harmful, pathogenic bacteria as well as how bacterial pathogens cause disease in the face of the ensuing inflammatory response.

We are specifically interested in the bacterial type III secretion system (T3SS), a specialized apparatus used by dozens of animal and plant pathogens to inject bacterial effector proteins inside target host cells. These effector proteins alter normal host processes and facilitate bacteria growth within the host.

We strive to understand how bacteria use the T3SS to optimize virulence as well as how the mammalian innate immune system recognizes T3SS deployment. We take advantage of this knowledge to identify small molecule inhibitors of the T3SS with the goal of developing biochemical tools and therapeutics. 

Currently, we are:

• Investigating how mammalian cells recognize T3SS+ Yersinia.
• Identifying previously unknown factors that control the Yersinia T3SS and virulence.
• Developing a series of high throughput screens for T3SS inhibitors.

Biography, Education and Training

B.A. Cornell University
Ph.D. UC Berkeley
Postdoc Tufts University School of Medicine